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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

PRICE PER SQUARE FOOT: $395
After Zhou contaminated the water, one of Zhou's classmates surnamed Tang noticed that the water coming out of the dispenser was milky and had a pungent scent.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

2、冷静自若。007总是很平静。(对男女来说都有用)。即便是在死到临头的时候,也很冷静。这就是性感啊。邦德从不慌张失措。你没见过邦德腿发软手发抖吧。他讲话时语速慢而谨慎,从不乱阵脚。这些都是极富魅力的品质,遭遇劲敌面不改色-这很容易让女人心动不已。他从不向女人表白个不停,就让她们猜不透,搞不懂,这样更加有吸引力。邦德不常微笑也为他的性感加分,因为有幸福感的男人吸引不了女人。007的肢体语言很强势,阳刚血性,从不畏惧;007从不喋喋不休,让他更加优雅;007从不懒散,挺拔的体姿不仅增加自信心,还有力量感,看起来更强壮(身着燕尾服与恶棍搏斗看起来更有档次)。
不管使用什么样的固有动力方式,所有这些引擎都利用最新的发动机技术,从而使性能和燃料经济最大化,其范围包括从福特嘉年华(Fiesta)的小型、高效1.0升涡轮增压三缸发动机到雪佛兰科尔维特Stingray已经被证明无可替代的巨大6.2升V8引擎。我们在本文的幻灯片里列出了《沃兹汽车》十大最佳引擎。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

popul人民+ation→人口

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

“有个女员工说自己去买靴子,但再也没露过面。”

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

This so-called “playground for millionaires” is now open to everyone. The wallet-friendly hotels, guesthouses and self-catering apartments make tours affordable. With more than 100 divine islands scattered on the Indian ocean, many activities await, such as sunbathing, fishing, diving, sailing, and going on boat tours. The Seychelles islands are blessed with a warm tropical climate all year round, so you can go there whenever you want.
Dachis says: Kraft took a stance in support of genetically engineered foods midway through the year and the decision turned their brand into an overall loser for 2012.
愿女儿的新年祝福带给你快乐。
卡利南和瑞兹各提一只装着所有奖项结果信封的手提箱——也就是说,每个奖项都有两只信封。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 2月 返乡置业“春节来袭”
Perspective

Trends and targets in antiviral phototherapy

[ai'dentiti]
No wonder that banks have begun to get creative.
"That of course is in keeping with all of the developments that we have seen in China in recent years, including the current enormous emphasis on innovation as a major component in the transition of the Chinese economy from 'Made in China' to 'Created in China'," he said.
Kay说我很一直很吃惊因为很多人都会告诉他们的同事找工作的事。这是你做的最糟糕的事情之一。理论上说你不能告诉任何同事,但是有时你不得不告诉他们因为想得到他们的引荐。如果那样的话Kay说,你得挑一些值得信任的人,他们不会背后秘密异议也不会口误说出去。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

杨燕绥说道,为确保该计划顺利进行,中央政府必须夯实统筹基础养老金,做大职业年金,管好个人账户。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

2.The Fresh Prince of Bel Air was Almost Bankrupt

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 18种情形失信企业将被列入黑名单
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

After weeks of nail-biting auditions and five days of tense semi-finals, Britain’s Got Talent picked one of the 11 acts to be the 2014 champion.
Cheng further says, "once you find a list that fits your needs, just tap on the list to see suggested locations. Then swipe right or left to see more options and tap 'read more' or the arrow at the bottom of the screen to select a venue and get more details.".

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 家具行业抄袭与被抄袭“同在”
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

历史学家希望解开有关理查三世的谜团,公开证据以反驳他杀害了两个年轻侄子的说法,重点关注他在位两年期间的成就,包括建立了保释制度和法律援助制度。
The 8 per cent year-on-year drop in profits last month compares with 4.2 per cent in November and is the biggest since the current data series began in late 2011, figures released on Tuesday showed.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

'In the meantime, the U.S. continues to grow its own domestic production both in oil and gas. I think, for us, it's less about where the actual price is going--it's more about how much more growth is left in North American oil sands, shale gas, shale oil,' as well as shale exploration elsewhere, he said.
该读数略低于经济学家的预期,不过总体上并不令人吃惊。上个月当中国央行(PBoC)出人意料地采取降息措施时,部分分析师就曾表示,此举可能是一种预防性措施,新出来的经济数据很可能较为疲弱。如今,事实正如他们的预期。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

The Office for National Youth Campus Football said that China already had 13,381 "special football schools" as of 2016, and 69 counties are piloting programs for football in schools, the Xinhua News Agency reported.
谎言3:是的,这挺有道理的。说谎原因:方案二会让我显得毫无头绪。
Hurricane Irma
Robin Harding

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

就这一点而言,他预计美国投资会回升,“因为投资一直太弱——除非在经济衰退期,我们通常不会看到投资增长低于消费增长”。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

今年世界卫生组织宣布H1N1型流感为全球性传染病。庆幸的是,这种病毒远没有人们最初想的那样危险,而最新面世的疫苗似乎已经平息了那弥留在人们心头久久不能散去的恐惧。
俄罗斯总统普京说,无论谁在明年的美国总统大选中胜出,他都希望改善与美国的关系。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

I give all my love to you this New year.值此佳节,献上我对你所有的爱。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 北京今年新增减税规模预计400亿
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

《生活真奇怪》

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
请接受我节日的祝贺。
Along with her friend Chloe, Max is out to uncover the truth behind the mysterious disappearance of fellow student Rachel Amber. With an indie-film feel and an eclectic soundtrack, Life Is Strange stands out from other games by blending the angst of being a teenage girl today with life-and-death situations, and the ability to rewind time. While this gameplay mechanic has been used in many games before, this take on time manipulation feels as unique as the American characters the French developer has created.
A review of our work in 2016

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

戛纳电影节素以质问与嘲笑著名。在本届电影节上,《青木原树海》(Sea of Trees)成为第一部遭遇观众挑剔的电影。该片由格斯?范?桑特Gus Van Sant指导。在媒体放映场,《青木原树海》遭遇嘲弄的风暴,陷入了嘘声之海。由于这些发生在首映红毯前,恶评迅速传播,使得盛典蒙上阴影。娜奥米?沃茨(Naomi Watts )和 马修?麦康纳(Matthew McConaughey)走上红毯时,《每日电讯报》(Daily Telegraph)形容此场景为“极其糟糕却又引人瞩目的羞辱之途”。但是在随后的新闻发布会上,马修?麦康纳,这位来自德克萨斯的演员表情坦然,“每个人都有权倒喝彩,正如他们有权喝彩一样,”他说道。我相信我们都知道他的意思。
刘易斯呼吁那些不能再照顾自己宠物的人们要联系家人、邻居或者动物收容所来接手这些动物。
It replaces strollers and big backpack carriers that might even make it heavier or cumbersome for you to take your children out.
[f?'ti:g]
Song “Give Me Your Love”(Zhang Jie and Yoga Lin)

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

It was all work, work, work for the BBC Culture team and parties, alas, were few and far between. But the rest of Cannes was painting the town red. In 2013 we tried to calculate the amount of champagne consumed at the festival by contacting Piper Heidsieck, “the official drink” of the festival, but they declined to comment – though judging by the merry faces and staggering gaits of some on the Croisette, it's safe to assume a colossal quantity. At the party for Matteo Garrone's Tale of Tales on the first weekend, the champers flowed freely and the revellers stayed on until the early hours. When the BBC's Rebecca Laurence spoke to one of its stars the following morning and asked how many hours sleep he'd had before their interview, he simply narrowed his bleary eyes and held up two fingers.
The image of a smooth-talking, chain-smoking and sexist James Bond may be a thing of the past as the latest 007 novel gives him a politically-correct makeover.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

vt. 超过,胜过,超出界限

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Recent initiatives to support two-way tourism between the two countries include the trial of the 10-year visitor visa; the open aviation market services arrangement which removes all capacity restrictions for airlines on both sides; and a new Beijing to Sydney service by Qantas Airways which was launched in January.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 水龙头材质是铅超标的“真凶”
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
"That of course is in keeping with all of the developments that we have seen in China in recent years, including the current enormous emphasis on innovation as a major component in the transition of the Chinese economy from 'Made in China' to 'Created in China'," he said.
这几年的实践可以证明,中国经济“硬着陆”论可以休矣。我们会长期保持中高速增长,并迈向中高端水平。
周二在马里兰的弗罗斯特堡沿着68号州际公路的交通瘫痪了。飓风桑迪带来的湿雪以及大风横扫西弗吉尼亚和邻近的阿巴拉契亚州部分地区并引发恶劣天气。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

These brands are close to their domestic markets, helping them to gain market share at the expense of global brands, and they are also winning share in new regions, according to BrandZ.
他补充称,在美国,在ETF兴起之际,市场上有很多注册投资顾问,他们有动力为客户选用成本较低的产品。
“In the drama, romance is the protagonist’s only pursuit. It seems that the meaning of her life is to have a romantic relationship with a Prince Charming. No, not only one, but three or four,” Douban user Jiuyuehuashang said.
"No one really knows how (end times) would look and how God would bring it about," Cox said.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

美国科学家Craig Bennett,Abigail Baird,Michael Miller,和George Wolford被授予搞笑神经科学奖,以奖励其在脑科学研究方面的贡献。他们的研究显示,利用复杂的设备加上简单的统计学方法,你几乎可以在任何地方得出有意义的脑活动研究结果——甚至是在一条死去的鱼身上也是如此!
这个习惯会严重影响你的工作。如果你认为在最后时刻可以发挥最好,不断地推迟任务直至最后一天(一个小时),你可能没有认识到你的这种习惯给同事们带来的影响。如果最后一刻再来赶工,要求别人迅速完成任务,很可能会惹恼你的同事,在任务失败或者未按时完成时候,你就是第一个被责备的人。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

尽管中国在设计制造能与波音737或空客A320媲美的大飞机上仍有很长的路要走,但发展趋势很显著。中国航空工业正走向一个崭新的发展阶段并不断迈向成熟。The first flight of the Comac C919. Credit: Comac
时间:2010-05-17 编辑:francie
Yes. Mr Meade is the candidate of the ruling Institutional Revolutionary Party, or PRI. His main rival is the hard leftist Andrés Manuel López Obrador, a passionate orator who can work a crowd. Mr Meade has a lot to overcome: he will have to convince voters that they can trust him, after he put up petrol prices by 20 per cent overnight in January, triggering a surge in inflation. He will also have to reveal himself as his own man, not just a clone of an unpopular government that has failed spectacularly to rein in rampant corruption and crime. But backed by the formidable PRI get-out-the-vote machine, he could prove unstoppable. In Mexico’s one-round-only system, 30 per cent of the vote might be enough.
完成所有的事,甚至更多
Ronaldo's monster pay-packet was the result of his eye-watering pound 38.5 million-a-year salary with Spanish giants Real Madrid and endorsement deals with the likes of Nike, watchmaker Tag Heuer and nutrition supplements group Herbalife - themselves worth pound 22 million.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

n. 娱乐
巴尼汤普森(Barney Thompson)是法律记者
全国31个省(区、市)1767所高校43万多名学生接受了调查。89.2%的受访者曾考虑过创业,18.2%的受访者称有强烈的创业意向。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 国务院:稳慎改革农村宅基地制度
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

胡润估计,如果此举获得成功,王健林的净财富可能会猛增至逾500亿美元,令他跻身世界前十大富豪之列。
As a measure of that fall, 10 works have sold at auction for more than $100 million since 2004, and all of them were made by modern or contemporary artists in the past 120 years. Older paintings have seen their value, in relative terms, level off or decline. The trend was plain to see in recent weeks, as London’s auction houses tried to find buyers for their latest tranche of old masters. As has been the case in recent years, there were few works by major names.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
From the themed collection: 黄改荣委员:扩大医保支付覆盖面
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

新兴市场出口额(以美元计算)下滑完全是一种价格效应,受到大宗商品价格下降的拖累。从数量上看,新兴市场出口自2014年以来一直持续上升,即便同比年增长率已放缓至2%左右——远远低于全球金融危机前后的两位数增长率,如第二张图表所示。
小牛队老板马克-库班曾下过比这更大的赌注,但是,他尝试换来诺埃尔作为空中接力/护框型球员——像泰森-钱德勒那样,舍弃的东西并不多(贾斯廷-安德森和一次伪第一轮选秀权)。
为什么会有这样的不同?原因并不是因为双方获得的信息不同。正如库迪斯和沃斯所指,荷兰金融圈里的每个人都知道和了解所发生事件的严重程度。也不是因为Seppenwolde的贷款机构不得不重建自身财务。违约几周后,贷款机构就知道他们没有损失一毛钱。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

这枚奖牌拍出的高价远远超过了该拍卖行预计的成交金额——5万美元到10万美元。此前,仅有1903年诺贝尔和平奖奖牌在1985年被拍卖,拍得将近1.7万美元。
Global smartphone shipments reached 1.47 billion units in 2016, up by 2.3 percent from last year, said IDC.
20. Best Advice for Movie Lovers In August, the scholar Wheeler Winston Dixon sounded an alarm: “If you go on Amazon and you see some great black-and-white film, and it’s going for $3, or any kind of foreign or obscure film, buy it, because it’s going out of print, and they’re not going to put them back into print.” Tens of thousands of films that were on VHS never made the jump to DVD or to Blu-ray, Mr. Dixon warns. And the brave new world of downloads (a.k.a. electronic sell-through) — well, tune in next year.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 京津冀将现“1小时通勤圈”
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 红木家具鉴定或引广州卖场效仿
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

几年前,有人发明了一辆会飞的自行车,叫做"Paravelo"。称一辆自行车会飞,并不是开玩笑,而是这辆自行车真的会飞(车头有一个巨大的降落伞)。它在陆地和空中的时速分别为25千米(15英里)和40千米(25英里),可飞至1200米(4000英尺)高空。最棒的地方是什么呢?那就是你不需要有飞行驾照。Paravelo号称世界上第一辆会飞的自行车,但我们必须指出它并不是第一辆会飞的自行车。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

祝来年好运,并取得更大的成就。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

勇士的横扫,实际上让那些试图挑战勇士的球队无力追赶勇士的脚步,致使联盟在季后赛收入上损失惨重。于是,总决赛便成了战胜勇士的最后的希望,也是最后的机会。总有些愚蠢的人通过不断告诉你不要低估了勒布朗·詹姆斯来让你重燃希望。我看了所有五场詹姆斯在的总决赛,我现在客观的告诉你:詹姆斯知道自己赢不了。“我能做什么?他们赢了73场比赛,我打败了他们,于是他们引进了凯文杜兰特。”在凯文杜兰特用自己的冷血投射杀死系列赛之前,骑士还设法在三场比赛中夺得了一场胜利。但最后,骑士队虽然避免了横扫的尴尬,但他们结束赛季的方式也只能用虎头蛇尾来形容。
Spielman was sifting through dirt at the Emek Tzurim national park on the slopes of the Mount of Olives in Jerusalem when she noticed the small rectangular object.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

年度最佳合唱:埃里克·丘奇、杰森·阿尔丁、卢克布·莱恩《The Only Way I Know》
连续4年以来,排行榜前5名的位置都被相同的五个跨洲EMBA项目所占据。Tiemba项目今年能够荣登榜首,不是因为它比竞争对手表现得异常优秀,而是得益于在大多数指标上的强劲表现。尤其是,该项目学员的平均薪资(32.4万美元)排名第二,仅次于凯洛格-香港科大(Kellogg-HKUST)EMBA项目的学员(40.8万美元)。Tiemba项目在职业晋升方面也位居第二,在工作经验方面排名第四。
马科斯卡瓦略是一名18岁的巴西球迷,本周早些时候,在巴西利亚国家体育馆闲逛的他表示:“我们甚至压根就没想过买票这事。门票太贵了,我们根本买不起,能做的也就是在家看看球了。我们看着去那些现场观战兴高采烈的人们,但我们自己却去不了,这真令人难过。”
The city offers excitement beyond your expectations, with grand churches, a richly varied number of museums, a growing modern-art scene and streets that come alive with summer festivals.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

平壤称Park为“人渣”,一直在谴责气球投放,最近几个月甚至要求首尔禁止这一行动。
During your early years wasthere anything that inspired or sparked your imagination to start writing theway that you have done so far?

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 郑州首套房贷款利率上浮10%成主流
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

从一开始,社交网络就被有效地隔离在互联网之外。比如,Facebook的海量内容通常不会显示在谷歌( Google )搜索结果之中。但是否非得是这种情形?比方说,Twitter搜索结果自动出现在一个标准的谷歌搜索显示页面,岂不是更方便?再比如,当你搜索Yelp时,为什么关于某家餐厅的最新Twitter消息没有显现出来呢?由于利益相悖,不同社交网络往往把各自的内容封锁在专利保护墙之内,但也有不少工具致力于创造性地弥合这道鸿沟。需要说明的是,本文作者的公司已经开发出了这样一种工具。
看看这些:

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

早在2008年,从测量心率到根据用户情绪播放音乐等的一系列可穿戴技术就已经被吹捧为消费电子产品的下一个重要契机了。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

They are also less likely to seek employment in a different sector after graduation. Only 30 per cent changed industry sector compared with nearly two-thirds of full-time MBA students.
回忆:fanfare(n 夸耀)
PBS' 'Vietnam War' series receives a special award.
你准备好惊悚一“夏” 了吗?《招魂2:恩菲德的骚灵》将于2016年6月10日上映。我们认为这将是一部非常好的恐怖片。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Europe fell into a debt crisis. Japan faced a natural disaster. Emerging markets, once the bright spots on the global landscape, lost their glow. Political crises from Italy to Egypt to Thailand raised the prospect of another round of global unrest.
5. Women keep rising.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

It was the age of wisdom, it was the age of foolishness…
今年的排行榜包括90个管理学硕士项目,创历来最高纪录,多于2015年的80个。
国内航空统计公司飞常准发布的最新报告显示,我国主要机场的准点率仍然远未让人满意。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 以房养老,如何把好事办好?
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

No. This crisis hit Amsterdam in 1772, after a respected Dutch investment syndicate made a disastrous bet on shares of the British East India Company.
15. An Amazing Coincidence One of the studios with the most on-screen diversity — it released “Trainwreck” and “Straight Outta Compton” (if also “Ted 2”) — and with the most female directors is Universal, which, as of early December, had gobbled up almost 24 percent of the year’s market share.
Pan Jiancheng, deputy head of the bureau's China Economic Monitoring and Analysis Center, said the increasing proportion of research and development expenditure to GDP indicates that the driving force of economic growth is transforming to innovation-focus from the traditional factors - exports and investment.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Trium’s alumni value studying alongside senior and international classmates. “It allowed us to exchange [ideas] among ourselves and derive as much additional knowledge as [we gained] from the course itself,” says one.
v. 劳累,拉紧,过份

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 险资牵手长租 助力楼市调控
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

9.Priyanka Chopra
这是充满希望的春天,也是令人绝望的寒冬……
同时,调查数据还显示,榜单上前100名的学校,毕业生平均月薪较去年上涨了1818元,涨幅达到22.8%。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

An escalating war on drugs in the Philippines has led to almost 1,800 deaths under new president Rodrigo Duterte, the country’s police chief has said.
Trailing behind "Game of Thrones" on the most downloaded list are "Breaking Bad" and "The Walking Dead." Here is the list of 2013's most-downloaded TV shows (single episode) according to data collected by TorrentFreak and BitTorrent trackers:

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

'With women, he has this sort of patronising carnal attitude with them which is absolutely accurate to the Bond of the books. But then by creating very strong women he is given quite a run for his money and his attitudes are challenged.
LBS tops the ranking of the best 81 business schools in Europe based on the schools’ performance in four of the rankings published by the FT each year: MBA, executive MBA (EMBA), masters in management (MiM) and executive education. (Two schools tied for 80th position with identical scores.)
Need to send gigantic files (up to 2gb) quickly? Try WeTransfer.com. You don’t even have to create an account. I use it almost every day.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 雄安新区政务服务中心启用开放
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Indeed, everyone from Jennifer Garner, to January Jones and Kylie Jenner have been photographed as they pick out their most spook-worthy pumpkins in time to send October out with a thrill.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

1. Technausea.
南韩的活动分子在星期二发誓,要在月底通过宣传气球跨越边境向北韩偷运荷里活讽刺片"刺杀金正恩",以作为对北韩不断威胁的反抗。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

继1958年瑞典世界杯之后,本届世界杯的场均进球数如狂潮般不断刷新。
●"Woman arrested for defecating on boss’ desk after winning the lottery"

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

巴韦贾对全球化不断变化的性质的深度分析显示,全球贸易增长疲软背后的主要因素是投资减速。全球贸易增速曾在很长一段时间内是全球GDP增速的两倍。
《橘色》,导演:肖恩·贝克(Sean Baker)。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.
v. 强调,着重

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

他说,本周早些时候他和美国国务卿克里的会谈显示,美国准备朝“解决只有通过共同努力方能解决的问题”的方向发展。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Wang, the chairman of Dalian Wanda Group, took the top spot with a personal fortune of $32.1 billion, the report said, despite Ma seeing his wealth surge 41 percent from 2015.
Sixty-one percent of Chinese college students who graduated in 2014 are satisfied with their current jobs, a survey has revealed.
欧洲专利局局长伯努瓦·巴迪斯戴利表示,中国公司专利申请量的增加,反映出中国加速扩张到欧洲、正成为一个知识型的全球创新型国家的事实。
cast

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

欧盟的美洲布局

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

地球大气中的二氧化碳浓度超过了百万分之400个单位
1936年诺贝尔和平奖奖牌在美国巴尔的摩的拍卖会上拍出116万美元高价,这枚奖牌是在南美的一家当铺里被发现的。
Everything Else

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

n. 结,节
So many are tuning out. Denial. Truth is, bubbles are everywhere. Ready to blow. The evidence is accelerating, with only one obvious conclusion: Max 98% risk at a flashpoint. This 2014 crash is virtually guaranteed. There's but a narrow 2% chance of dodging this bullet.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 2016家居行业必须关注的四件大事
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

她的亲妹妹莱克西经常装扮成电影中艾丽莎的妹妹、安娜公主,和姐姐一起同台演出,当莱克西抽不出时间的时候,她的好朋友们也会来帮忙。
We will speed up the reform of SOEs and state capital.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

It might be that bit too far from the mainstream to make a huge awards impact.
父母获得孩子尊重的7种方法
The survey found the majority of grads, or 73.5 percent, have found jobs, while the number of students set to continue their studies in China accounted for just 6.3 percent, sharply down from 16.5 percent in 2016.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

China has recently made majordecisions about its economic future. On November 15, 2013, China announceddramatic new social and economic policies contemplating much greater relianceon market forces than it has in the past and inviting private-sectorparticipation and foreign competition in industries long previously controlledby the central government. It also relaxed its one-child policy, openingthe country and its people to vast new opportunities and inspiring new hopes anddreams.
蓝天在未来不会也不应该成为奢侈品。
●Van Full Of Illegals Shows Up To Vote Clinton At SIX Polling Places, Still Think Voter Fraud Is A Myth?
●"President Obama Confirms He Will Refuse To Leave Office If Trump Is Elected"

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Technically it is a project of the 10-member Association of Southeast Asian Nations to bring all of its trade deals in the region under one umbrella. It also lacks the ambition on many fronts of the TPP.
支持两国之间双向旅游的最新倡议包括以下几点:审查10年旅游签证;安排开放的航空市场服务以消除双方航空公司的所有容量限制;Qantas航空公司于1月推出北京到悉尼的新服务等。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

把职工安置好还是我们推进供给侧结构性改革,推动化解和淘汰过剩产能中最关键的问题。
3. 没有开始创业
高盛将大派红包,饱受各方抨击一个月,然后静悄悄地干回自己的老本行--挣钱。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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持有40亿美元亚洲相关资产的美国投资机构Cohen & Steers的基金经理梁纬濂(William Leung)认同这一点。他主张,随着价格下跌,投机性投资将被驱逐出市场。他补充称,行业中另类投资热度上升的趋势应当意味着,即便基础资产的价值上涨得更慢,房地产投资信托的价格也会上升。“我们认为,这次调整的幅度将不会太大,”他说。
A median forecast from economists had predicted a 0.9 per cent rise.

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